Proton pump inhibitors and acute kidney injury: a nested case–control study
نویسندگان
چکیده
منابع مشابه
Proton pump inhibitors and acute kidney injury: a nested case–control study
BACKGROUND Proton pump inhibitors (PPI) are a widely-used class of drugs for the treatment of gastro-esophageal reflux disease and other acid-related disorders of the gastrointestinal tract. As a class, PPIs have demonstrated a favorable safety profile. However, case reports have suggested that this class of drugs may be linked to acute kidney injury, which may in turn lead to chronic injury or...
متن کاملLong-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury.
Proton pump inhibitor (PPI) use is associated with an increased risk of acute kidney injury (AKI), incident chronic kidney disease (CKD), and progression to end-stage renal disease (ESRD). PPI-associated CKD is presumed to be mediated by intervening AKI. However, whether PPI use is associated with an increased risk of chronic renal outcomes in the absence of intervening AKI is unknown. To evalu...
متن کاملProton-pump inhibitors use, and risk of acute kidney injury: a meta-analysis of observational studies
BACKGROUND Recent studies have suggested a potential increased risk of acute kidney injury (AKI) among proton-pump inhibitor (PPI) users. However, the present results are conflicting. Thus, we performed a meta-analysis to investigate the association between PPI therapy and the risk of AKI. METHODS EMBASE, PubMed, Web of Science, and Cochrane Library databases (up to September 23, 2016) were s...
متن کاملProton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study.
BACKGROUND Proton pump inhibitors (PPIs) cause interstitial nephritis and are an underappreciated cause of acute kidney injury. We examined the risk of acute kidney injury and acute interstitial nephritis in a large population of older patients receiving PPIs. METHODS We conducted a population-based study involving Ontario residents aged 66 years and older who initiated PPI therapy between Ap...
متن کاملProton Pump Inhibitors Are Not Associated With Acute Kidney Injury in Critical Illness.
Recent epidemiologic data linking proton pump inhibitor (PPI) use to acute and chronic kidney dysfunction is yet to be validated in other populations, and mechanisms have not been explored. Using a large, well phenotyped inception cohort of 15 063 critically ill patients, we examined the risk of acute kidney injury (AKI), as defined by the Kidney Disease Improving Global Outcomes criteria guide...
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ژورنال
عنوان ژورنال: BMC Nephrology
سال: 2013
ISSN: 1471-2369
DOI: 10.1186/1471-2369-14-150